Name | Mal-amido-(CH2COOH)2 |
Synonyms | Mal-amido-(CH2COOH)2 MAL-AMIDO-(CH2COOH)2 Glycine, N-(carboxymethyl)-N-[3-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxopropyl]- |
CAS | 207613-14-7 |
Molecular Formula | C11H12N2O7 |
Molar Mass | 284.22 |
Density | 1.580±0.06 g/cm3(Predicted) |
Boling Point | 620.2±50.0 °C(Predicted) |
pKa | 2.91±0.10(Predicted) |
In vitro study | Mal-amido-(CH2COOH)2 is a intermediate for linker. Bivalent doxorubicin (DOX)-dipeptides (16a-c) are finally prepared and conjugated to the monoclonal antibody BR96. The dipeptides are cleaved by lysosomal proteases following internalization of the resulting immunoconjugates. |
In vivo study | ADC Linker |
biological activity | Mal-amido-(CH2COOH)2, compound 7a, can be used to synthesize hydrophilic ADC linker, it is an intermediate containing ethyl maleimide. |